AIM: To observe and evaluate clinical effect of the combined use of vitamin A palmitate eye ophthalmic gel and Ellie eye drops for the treatment of various eye surface damage.

METHODS:Totally 167 cases of corneal disease were randomly divided into Ellie eye drops treatment group(n=45), vitamin A palmitate eye ophthalmic gel(n=55)in treatment group, the combined use group(n=67). Ellie eye drops were used to drop eye every 2 hours a day(daily 6 times). Vitamin A palmitate eye ophthalmic gel treatment group was used every 2 hours a day(daily 6 times), eye drops 1 time before sleeping in the evening. The combined use group was treated according to the above method of two medicines with 5 minutes interval.

RESULTS: Cure rate and the total effective rate of vitamin A palmitate eye ophthalmic gel treatment group were 56.4% and 83.6% respectively. Cure rate and the total effective rate of Ellie eye drops group were 66.7% and 88.9% respectively. Cure rate and the total effective rate of combined use group were 83.6% and 97.0% respectively. Alone use of Ellie eye drops in various eye surface damage was more efficient than vitamin A palmitate eye ophthalmic gel. The efficacy of combined use group for the treatment of various eye surface damages was obviously higher than that of the single application group(P<0.05). Local stimulation and systemic adverse reactions were not found during the observation.

CONCLUSION: Ellie eye drops is more effective than vitamin A palmitate eye ophthalmic gel for the treatment of all kinds of ocular surface damage, but the two medicine combined application treatment is much safer and more specific than the alone application.