Abstract:AIM: To investigate the relationship between pathological myopia and the LAMA1 gene.
METHODS: Individuals with pathological myopia and control subjects of Chinese Southern Han were selected. Genomic DNA was collected from 5mL peripheral blood, then the exon27, exon36 in the LAMA1 gene were analyzed by polymerase chain reaction(PCR)and direct sequencing. Allele frequencies were tested for Hardy-Weinberg equilibrium(HWE). The χ 2 Fisher test was conducted to investigate the genotypic and allelic distri-bution between the pathological myopia and control groups.
RESULTS: In this study, no gene mutation was identified in the exon27, exon36 in the LAMA1 gene.
CONCLUSION: The relationship between pathological myopia and the LAMA1 gene is still waiting for the further proof.
