AIM: To observe the clinical effect and recurrence rate of biological amnion transplantation in pterygium operation, and to provide the reference for pterygium diagnosis.

METHODS: Fifty-two patients(58 eyes)with pterygium were conducted microscope excision combined with biological amnion transplantation from April, 2010 to September, 2012. The repair time of corneal epithelium and postoperative recurrence rate were recorded. Forty-six patients(53 eyes)receiving excision of pterygium with microscope alone at the same term were selected to make a controlled study.

RESULTS: The recurrence rate of patients in research group was significantly lower than that in control group. The proportion of healing cases in research group on the 3^rd and 5^th days after operation were remarkably higher than that in control group, while that on the 14^th day conspicuously lower than that in control group. The mean healing days of patients in research group were markedly shorter than that in control group. In addition, the patient comfort of the research group was significantly higher than that in control group.

CONCLUSION: Excision of pterygium with microscope combined with biological amnion transplantation can effectively shorten the postoperative repair time of corneal epithelium, decrease the recurrence rate distinctly, and is more comfortable, so it deserves to be recommended.