AIM: To observe and analyze the side effects of fluorescein sodium injection in fundus fluorescein angiography.

METHODS:The incidence of side effects and corresponding treatments of 1 759 patients in fundus fluorescein angiography from June 2010 to July 2012 were reviewed and analyzed.

RESULTS:Totally, 267 out of 1759(15.17%)patients had side effects, nausea was reported in 181 cases(10.29%), vomiting in 32 cases(1.82%), sneezing in 6 cases(0.34%), itchy skin and rash in 27 cases(1.53%), itchy throat and cough in 8 cases(0.45%), a transient palpitation and chest tightness in 8 cases(0.45%), dizziness, chest tightness, fatigue and cold sweat in 5 cases(0.28%).

CONCLUSION: Fluorescein sodium injection can cause the side effects of varying severity, mostly minor side effects. However, indications and contraindications should be strictly controlled and preparation for severe side effects should be ready during treatment to ensure patient safety in case of emergency.