AIM: To investigate and analyze corneal edge ulcer training results, pathogenic bacteria distribution and drug resistance status of fungal keratitis.

METHODS:Corneal edge ulcer of 68 fungal keratitis patients who were treated in our hospital from January 1, 2011 to December 31, 2012 was collected. They were sent to isolate culture, identification and drug sensitive test. The culture and drug sensitive test results, and pathological changes of corneal tissue were summarized.

RESULTS:Fifty strains of fungi strains were checked out from 68 corneal edge ulcer, most of them were sickle bacteria genus. The resistant rate of natamycin, fluconazole, amphotericin and itraconazole was 26%, 46%, 54% and 60%, respectively.

CONCLUSION: The most pathogenic bacteria were sickle bacteria genera, the resistance of amphotericin and itraconazole is higher, while that of itraconazole is lower.