AIM: To observe the effect of Zhengyuanyunsheng dripping pills for non-proliferative diabetic macular edema(DME).

METHODS: Fundus fluorescein angiography(FFA)and optical coherence tomography(OCT)were used in diagnosis of non-proliferation in patients with DME in 40 cases(76 eyes). The cases were randomly assigned to the treatment group(20 cases, 40 eyes)and the control group(20 cases, 36 eyes). The cases in the treatment group were given conventional treatment, and those in the control group received Zhengyuanyunsheng dropping pill. After 3 months, macular retinal thickness and the best vision correction were recorded and compared.

RESULTS: Fade rate of macular edema in the control group and the treatment group were 13 eyes(32.5%)and 24 eyes(66.7%), the difference was statistically significant(P<0.05). The best vision correction in treatment group was better than that in the control group(P<0.01).

CONCLUSION: The Zhengyuanyunsheng dripping pills has obvious curative effect on macular edema and BCVA for the patients with diabetic retinopathy.