AIM: To observe and describe the clinical manifestations of multiple evanescent white dot syndrome(MEWDS).

METHODS:The clinical data of 25 cases diagnosed as MEWDS from January 2003 to November 2012 in our hospital were retrospectively analyzed. A variety of imaging data were analyzed, and the clinical and imaging features of MEWDS were summarized.

RESULTS: All patients with mild to moderate myopia, visual field defect in different degree. Fluorescein angiography(FFA MEWDS)showed: the lesions showed round strong fluorescent spot, with time delayed fluorescence intensity, advanced showed strong fluorescence boundary was not clear staining, optic disc fluorescence enhancement, accompanied by a segment of vascular wall staining. Indocyanine green angiography(ICGA)showed: the relative weak fluorescence early posterior interspersed with different size, advanced gradually with clear boundaries of patchy fluorescence. OCT showed: location photoreceptive cells layer thickness, photoreceptor inner segments of irregular/outer segment(IS/OS)layer band local thin or missing, with reflective intensity(abnormal fluorescence foci of the part and angiography in the corresponding), and retinal inner plexiform layer and outer nuclear layer were no obvious abnormalities.

CONCLUSION: MEWDS patients with fundus spot like lesions are characteristic in FFA, ICGA, OCT, these features suggest that the lesions were located in the RPE and photoreceptors, these features of MEWDS disease diagnosis and differential diagnosis.