AIM: To compare the retinal macular thickness and macular volume between amblyopic eyes and non-amblyopic eyes in adolescent with unilateral anisometropic amblyopia by optical coherence tomography(OCT).

METHODS: Thirty-one juveniles with unilateral anisometropic amblyopia were selected. Macular retinal thickness and macular volume were measured by OCT with both eyes in all participants, and the differences between amblyopic eyes and non-amblyopic eyes were compared. Axial length(AL)was measured by A-ultrasound. The relationship between AL and the factors of macula was analyzed.

RESULTS: The central sector region and the nasal inner region in amblyopic eyes were thicker than those in normal eyes(P=0.0358, 0.0003), but there was no significant difference in any other region between amblyopic eyes and normal eyes(P>0.05). No significant difference was found in macular volume between amblyopic eyes and normal eyes(P>0.05). The factors of the macula in both eyes were not significantly related to the AL.

CONCLUSION: There exists some difference in structure of macula between amblyopic eyes and non-amblyopic eyes in adolescent with unilateral anisometropic amblyopia.