Proliferative vitreoretinopathy(PVR)is a disease process that follows the proliferation of ectopic cell sheets in the vitreous and/or periretinal area, causing periretinal membrane formation, shrink and traction, in patients with rhegmatogenous retinal detachments. Pars plana vitrectomy is the standard treatment currently. There are many new drug therapies according to the functions of cytokines and growth factors in PVR, including anti-inflammatories, antineoplastic agents, antigrowth factors, and so on.