AIM: To observe the effects of using 0.1g/L mitomycin-C(MMC)to prevent the formation of haze in laser-assisted subepithelial keratomileusis(LASEK)for moderate and high myopia.

METHODS: Totally 78 cases(156 eyes)were randomly divided into two groups. With group MMC including 86 eyes, 0.1g/L MMC and balanced salt solution(BSS)within sponges dip the ablated zone; The control group(70 eyes)used BBS in the same way. Uncorrected visual acuity(UCVA), corneal epithelial healing time, and the formation of corneal haze 1, 3, 5 and 7d; 2wk; 1,3 and 6mo after surgery were observed.

RESULTS: The incidence of haze of group MMC was lower than the control group, the difference was statistically significant(P<0.05); the corneal epithelial healing time and the postoperative UCVA between the two group had no significant difference(P>0.05).

CONCLUSION: The application of 0.1g/L MMC during LASEK can prevent the formation of haze.