AIM:To assess the biocompatibility of hydrophobic acrylic intraocular lenses after anterior surface modification with monomer vinyl pyrrolidone by studying cell adhesion using light microscopy.

METHODS: Twenty-six eyes of 13 rabbits were divided into 3 groups randomly. Nine eyes were implanted into vinyl pyrrolidone modification intraocular lenses, 8 eyes were implanted into titanium oxide modification intraocular lenses, 9 eyes were implanted into unmodified intraocular lenses following lens extraction. The intraocular lenses implanted eyes were enucleated in 90d of post operation and cell adhesion on surface of different intraocular lenses were compared under light microscopy.

RESULTS: The cells' size, number and protein films of intraocular lenses on anterior surface of vinyl pyrrolidone modification group were significantly less than that in two control groups.

CONCLUSION: The uveal biocompatibility of hydrophobic acrylic intraocular lenses after single surface modification by monomer vinyl pyrrolidone is significantly improved.