AIM: To assess the morphological features, classification, and contrastive analysis between the features of optical coherence tomography(OCT)and fundus fluorescein angiography(FFA)in clinically high myopic maculopathy.

METHODS: Totally 61 patients(101 eyes)with clinically high myopic maculopathy. Distant vision was examined through E Standard Logarithm Eyesight Table. Integrated optometry to determine the dioptre and best corrected visual acuity(BCVA). Axial length(AL)measurements obtained through IOL-Master. Fundus examinations performed in patients with high myopia after pupil dilation. OCT and FFA were done separately in each case of myopic maculopathy on the same day. FFA and indocyanine green angiogrsphy(FFA& ICGA)was done if need be. The correlation between FFA types and OCT types were analyzed, and their associations with dioptre, BCVA, AL and central foveal thickness were evaluated.

RESULTS: The prevalence of lacquer crack type was higher in the OCT type 1(57.14%)than in the choroidal neovascularization(CNV)type and macular atrophy type(21.43%)of fluorescein angiography, the difference was statistically significant(P<0.05). The prevalence of macular atrophy type was higher in the OCT type 2(67.80%)than in the lacquer crack(18.64%)and CNV type(13.56%), the difference was statistically significant(P<0.05). The macular atrophy type all belong to the OCT type 3. OCT type 1 showed the least dioptre and AL, conversely the highest central foveal thickness and/or BCVA(P<0.05). There was no obvious difference between lacquer crack type and CNV type on diopter and AL, but lacquer crack type showed better BCVA and foveal thickness(P<0.05). The diopter and AL of lacquer crack type and CNV type were significantly lower than that of macular atrophy type, while BCVA was higher(P<0.05).

CONCLUSION: There was a significant correlation between the features of OCT and FFA in high myopicmaculopathy. The analysis of clinically high myopic maculopathy based on combination of OCT and FFA can provide information that may be useful to make sure the nature of high myopia, disclose the pathogenesis and to optimize the treatment for each type.