Abstract:AIM: To investigate the effect and complication of sodium hyaluronate combined with Ahmed glaucoma valve implantation on neovascular glaucoma(NVG).
METHODS: This was a retrospective observational case series. Forty-nine patients(49 eyes)with NVG in our hospital from 2009 to 2011 were randomly divided into two groups according to the odd-even of medical record number. Ahmed glaucoma valve implantation proceeded separately in control group, while in control group combined with 0.2-0.3mL sodium hyaluronate, regularly follow-up after operation at 1mo, comparing the complications such as postoperative intraocular pressure(IOP), the changes of best corrected visual acuity(BCVA), the hemorrhage of shallow anterior chamber, hyphema and choroidal detachment, etc. IOP before and after operation between the two groups was examined by independent sample test(non-normal distribution), the complications were compared by χ2 text.
RESULTS: Postoperative follow-up time was 1mo. IOP in research group was declined from 42.8±5.56mmHg preoperatively to 17.7±3.77mmHg, IOP in control group was declined from 42.5±5.36mmHg preoperatively to 18.6±5.39mmHg. Postoperative complications: shallow anterior chamber occurred in 2 patients(2 eyes)in research group and 4 patients(4 eyes)in control group. Hyphema occurred in 1 patient(1 eye)in research group and in 5 patients(5 eyes)in control group. Poor location of the anterior chamber silicone tube occurred in 1 patient in research group.
CONCLUSION:Sodium hyaluronate combined with Ahmed glaucom avalve can effectively reduce IOP in patients with NVG and decrease the postoperative hyphema, which will lead to short-term increasing IOP in patients after operation, but had no significant effect in the long run.
