白内障术后临床体征与干眼症之间的关系
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Relationship between clinical signs and dry eye symptoms after cataract surgery
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    摘要:

    目的:为了评估传统的和新的临床试验\〖眼睑刷上皮病变(LWE),睑缘平行的结膜皱褶(LIPCOF)\〗与白内障术后3mo干眼症状之间的关系,能够提高预测干眼症状发展趋势的这些测试。

    方法:选取患有非干眼症的白内障患者43例43眼,对其行白内障超声乳化吸除术。采用新的临床测试对白内障术后干眼症状进行评估,泪河高度(TMH),LIPCOF,酚红棉线测试(PRTT),角膜和结膜染色,眼睑刷上皮病变(LWE)分级。采用SPSS 19.0 统计软件,对数据进行统计学分析。使用眼表疾病指数量表(OSDI)评估症状。

    结果:LWE与鼻颞侧的LIPCOF有显著相关性的(P<0.05)。LIPCOF,LWE与NIBUT和PRTT有显著相关性(P<0.01)。TMH与PRTT之间发现有显著的相关性(P<0.01)。OSDI分数与TMH,PRTT,LIPCOF及LWE之间有显著的相关性(P<0.05)。OSDI+/-是鼻侧LIPCOF\〖受试者工作特性曲线(AUC)下面积(AUC=0.803),TMH(0.706),PRTT(0.755),LIPCOF(颞侧/总数,0.725/0.763)和LWE(0.727)等重要鉴别指标\〗。鼻侧LIPCOF测试具有最佳的预测能力。

    结论:分别测试TMH,PRTT,LIPCOF和LWE的显著性,与OSDI分数呈适度相关性。

    Abstract:

    AIM: To evaluate the relationship between clinical tests(traditional and new)\〖lid-wiper epitheliopathy(LWE), lid-parallel conjunctival folds(LIPCOF)\〗 and dry eye symptoms after 3mo of phacoemulsification. The combination of these tests can improve predictive ability for the development of dry eye symptoms.

    METHEDS: Tear film was monitored in 43 patients(43 eyes)afterphacoemulsification. A new clinical test was used to evaluate the dry eye symptoms after surgery. Tear meniscus height(TMH), LIPCOF, phenol red thread test(PRTT), corneal and conjunctival staining and LWE grades were observed. The results were analyzed by using SPSS 19.0. Symptoms were assessed by using the ocular surface disease index(OSDI).

    RESULTS:LWE was significantly correlated to nasal nasal and temporal side LIPCOF(P<0.05). LIPCOF and LWE were significantly correlated to NIBUT and PRTT(P<0.01). Significant correlations were found between TMH and PRTT(P<0.01). OSDI scores were significantly correlated to TMH, PRTT, LIPCOF and LWE(P<0.05). Significant discriminators of OSDI+/- were nasal LIPCOF \〖area under the receiver operating characteristic curve(AUC)(0.803), TMH(0.706), PRTT(0.755), LIPCOF(temporal/sum, 0.725/0.763)and LWE(0.727), etc\〗. Best predictive ability was achieved by nasal LIPCOF.

    CONCLUSION: The individual tests TMH, PRTT, LIPCOF and LWE were significantly but moderately related to OSDI scores.

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沈明海,房传凯.白内障术后临床体征与干眼症之间的关系.国际眼科杂志, 2014,14(3):538-541.

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  • 收稿日期:2013-12-16
  • 最后修改日期:2014-02-14
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  • 在线发布日期: 2014-02-27
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