AIM: To analyze features of optical coherence tomography(OCT)in Vogt-Koyanagi-Harada syndrome before and after therapy.

METHODS: Thirty-four eyes of 17 patients, which were identified as Vogt-Koyanagi-Harada syndrome, were examined with OCT and fundus photography, after the treatment of steroid therapy, the change of retinal structure were observed after 5, 15, 30d.

RESULTS: OCT revealed retinal neuroepithelial edema and serous detachment of retinal neuroepithelia and subretinal septa that divided the subretinal space into several compartments all of cases. After steroid therapy, the retinal edema, serous detachment and subretinal septa were improved, even resolved completely.

CONCLUSION: OCT can observe retinal structural change of Vogt-Koyanagi-Harada syndrome before and after therapy, it is vital for diagnosis and treatment evaluation of the disease.