AIM: To investigate the efficacy of Mitomycin C(MMC)for patients with refractory glaucoma and its influence on the serum vitamin and interleukin.

METHODS: Patients with refractory glaucoma from January 2010 to January 2013 were randomly divided into control group(compound trabeculectomy treatment group)with 80 cases and observation group(MMC combined with compound trabeculectomy treatment group)with 80 cases, then the difference in efficacy between the two groups were counted, and the intraocular pressure, visual acuity and the levels of FA, VB12, VB6, IL-2 and IL-6 of two groups before and after the treatment were also been compared.

RESULTS: The surgical success rate of observation group was 80.9% which was significantly higher than that of control group(60.7%); after the surgery, the intraocular pressure of observation group were all lower than that of control group, and the visual acuity was better than that of control group, all P<0.05. The levels of FA, VB12, IL-2 and IL-6 of failed surgery group were significantly lower than that of control group and successful surgery group(P<0.05). The levels of FA, VB12, IL-2 and IL-6 of observation group at 3mo after the treatment were all higher than those indexes of control group,all P<0.05.

CONCLUSION: Combined with MMC could effectively improve surgical success rate of refractory glaucoma, and improve the indicators of serum vitamin, interleukin.