AIM: To observe the efficacy of deproteinated extract of calf blood ophthalmic gel with artificial tears local eye drops in treatment of dry eye.

METHODS: A randomized, parallel-control approach was adopted, 150 patients(300 eyes)with dry eye were divided into treatment group and control group equally(75 cases, 150 eyes). The treatment group was applied Dextran and Hypromellose eye drops combined with deproteinated extract of calf blood ophthalmic gel, simply Dextran and Hypromellose eye drops for control group. Clinical symptoms, SchirmerⅠ test(SⅠt), break-up time(BUT), corneal fluorescein staining and tear protein were observed. Therapeutic observation was 3mo.

RESULTS: BUT, SⅠt, and corneal fluorescein staining have statistical significance before and after treatment(P<0.05 or P<0.01), the changes in treatment group were obviously superior to that in control group(P<0.05). The total clinical effect satisfaction rates were 96% for treatment group and 75% for control group, curative effect in treatment group was obviously superior to control group(P<0.05). Tear protein was significantly improved in treatment group(P<0.05).

CONCLUSION: The deproteinated extract of calf blood ophthalmic gel with artificial tears local eye drops perform better than artificial tears eye drops only in treatment of dry eye.