方法：收集2013-08/09于我院行飞秒激光制瓣LASIK并随访3mo的患者120例240眼，观察术前、术后1wk； 1，2，3mo患者的Oculus角膜地形图仪检查的泪膜破裂时间(tear break-up time，BUT)、Oculus角膜地形图仪检查的泪河高度(tear meniscus height，TMH)。

结果：Oculus BUT：术后1wk； 1，2mo与术前相比有显著差异(P=0.012，0.000，0.023<0.05)，术后3mo与术前相比无显著差异(P=0.236>0.05)。泪河高度：术后1wk； 1，2mo与术前相比有显著差异(P=0.025，0.019，0.026<0.05)，术后3mo与术前相比无显著差异(P=0.375>0.05)。

结论：飞秒激光制瓣准分子激光原位角膜磨镶术在一定时间和一定程度上影响泪膜的稳定性，发生机制与多种因素有关，持续时间比较短，症状比较轻。

METHODS:Totally 120 myopic patients(240 eyes)were collected who underwent femtosecond laser surgery LASIK from August to September 2013, and these patients can be followed up for 3mo. Tear break-up time(BUT)and tear meniscus height(TMH)with Oculus corneal topography were recorded preoperatively and postoperatively at 1wk; 1, 2 and 3mo.

RESULTS: Oculus BUT: there existed obvious differences(P=0.012, 0.000, 0.023<0.05)in 1wk, 1 and 2mo compared with the preoperative level. While no such obvious difference(P=0.236>0.05)existed in 3mo compared with the preoperative level. TMH: there existed obvious differences(P=0.025, 0.019, 0.026<0.05)in 1wk, 1 and 2mo compared with the preoperative level. No such obvious difference(P=0.375>0.05 )existed in 3mo compared with the preoperative level.

CONCLUSION: Femtosecond laser surgery affects the stability of the tear film at a certain time and a certain extent. The mechanism related to many factors. It is temporary and lighted.