AIM: To study the effectiveness of hyaluronidase periocular injection combined with α-lipoic acid and Chinese medicine in the treatment of diabetic vitreous hemorrhage.

METHODS: Retrospective analysis of 67 patientswith proliferative diabetic retinophathy(PDR)and vitreous hemorrhage, were divided into two groups: treatment group and control group. There were 32 cases in every group, the treatment group were giving hyaluronidase periocular injection combined with α-lipoic acid intravenously and with traditional Chinese medicine in promoting blood circulation to remove blood stasis, control group were only given Chinese medicine treatment in promoting blood circulation to remove blood stasis.

RESULTS: Followed up 2-3mo, the total efficiency of treatment group(78%)was better than control group(57%), there was statistically significant difference(P<0.05). The efficiency of the two groups' patients with vitreous hemorrhage more than 2wk time was 22% and 25% respectively, there was no statistically significant difference in the two groups(P>0.05).

CONCLUSION: Hyaluronidase periocular injection combined with α-lipoic acid and Chinese medicine in the treatment of PDR combined with vitreous hemorrhageis more effective than only use Chinese medicine. But it only has effect for the early, over 2wk, it has no significant effect.