AIM: To analyze the correlation between tear film changes of allergic conjunctivitis and dry eye, then provide clinical references for better treatment.

METHODS: Fifty patients with allergic conjunctivitis were taken as the observation group, the control group was selected based on 1:1 case control theory, and we chose 50 health volunteers without ocular surface diseases, xerophthalmia and systematic diseases randomly, then fluorescein(FL)staining, break-up time(BUT), Schirner I test(SⅠt), tear meniscus high(TMH)and slit-lamp examinations were performed in the two groups.

RESULTS: In the observation group, FL, BUT, SIt, TMH of right eyes and left eyes were statistically significant correlated(P<0.05). FL and BUT were statistically significant between control group and observation group(P<0.05). TMH and SIt has positive correlation, while FL and BUT has negative correlation and the differences were statistically significant(P<0.05).

CONCLUSION: Due to inflammatory mediators participation, allergic conjunctivitis could lead to the stability changes of tear film which cause in dry eye. The stability changes of allergic conjunctivitis correlate to the damage degree of epithelium.