AIM: To observe the changes of tear film on the patients after laser in situ keratomileusis(LASIK)with corneal flap created by femtosecond laser with the different gender.

METHODS: The 120 myopic patients(240 eyes)who underwent femtosecond laser surgery LASIK from August to September 2013 were collected, and these patients were followed up for 3mo. The patients were divided into two groups according to the gender, group A was male(110 eyes of 55 patients); group B was female(130 eyes of 65 patients). Dry eye symptom score, tear break-up time(BUT), Schirmer Ⅰ test, corneal fluorescein staining were recorded preoperatively and postoperatively in 1wk,1,2,3mo.

RESULTS: Dry eye symptom score: it was statistically significant between two groups after operation in the 1wk,1, 2mo(P=0.000,0.023, 0.030). It had no statistical significance between the two groups in 3mo(P=0.283). BUT: it was statistical significance between two groups after operation in the 1wk,1, 2, 3mo(P=0.000,0.017, 0.026, 0.032). SchirmerⅠ test: it was statistically significant between two groups after operation in the 1wk, 1, 2mo(P=0.012,0.024, 0.018). It had no statistical significance between the two groups in 3mo(P=0.206)Corneal fluorescein staining: it was statistically significant between two groups after operation in the 1wk, 1, 2, 3mo(P=0.022,0.015, 0.036, 0.041).

CONCLUSION: The influence of tear film after femtosecond laser surgery for men less than that for women.