AIM: To evaluate the clinical efficacy and safety of photodynamic therapy(PDT)on choroidal neovascularization(CNV)caused by age-related macular degeneration(AMD), pathological myopia(PM), and central exudative chorioretinopathy(CEC).

METHODS: A retrospective observation on the clinical data of 53 AMD patients(53 eyes)from January 2010 to December 2012, diagnosed CNV through fundus fluorescein angiography(FFA), indocyanine green angiography(ICGA)and optic coherence tomography(OCT), treated with PDT. The changes of best corrected visual acuity(BCVA)and central macular thickness(CMT)were compared before and 1a after treatment.

RESULTS: At the last follow-up, the BCVA was improved in 35 cases, stabilized in 15 cases and decreased in 3 cases. Fundus hemorrhage and exudation reduction after PDT was observed in all patients. FFA and OCT showed complete closure of CNV in 42 cases, partial closure in 11 cases. The visual acuity and CMT changes were statistically significant. No serious adverse event related to PDT.

CONCLUSION: PDT is helpful for maintaining the visual acuity of wet-AMD within 1a and the incidence of the adverse response is low, which suggest that PDT is an effective and safe treatment for CNV in patients of AMD.