AIM: To evaluate the curative effect and drug tolerance in the treatment of severe bacterial keratitis and conjunctivitis by levofloxacin.

METHODS: Totally 195 patients with severe bacterial keratitis and conjunctivitis were included in this study. Based on the sequence of enrollment, they were randomly divided into three groups: group A(65 patients)received levofloxacin, group B(65 patients)received suture method under microscope, group C received suture method with loupe besides the same basic operative treatment in the two groups. The curative effect and drug tolerance were observed and compared statistically.

RESULTS: In group A, 54 cases were cured, in the rate of 83.1%, 7 cases(10.8%)were excellent, 3 cases(4.6%)were valid, 1 case(1.5%)was invalid. In group B, 25 cases(38.5%)were cured, 6 cases(9.2%)were excellent, 23 cases(35.4%)were valid, 11 cases(16.9%)were invalid. In group C, 4 cases(6.2%)were cured, 3 cases(4.6%)were excellent, 36 cases(55.4%)were valid, 22 cases(33.8%)were invalid. The curative effect and drug tolerance among groups had obvious differences(P<0.05).

CONCLUSION: Levofloxaoin is effective and safe for the treatment of bacterial conjunctivitis and keratitis, which is not resistant and worthy of promotion.