AIM: To analyze the pathogens and drug sensitivity of chronic dacryocystitis in order to provide evidence for clinical drug use.

METHODS: Lacrimal secretion of 171 cases with chronic dacryocystitis was sampled for pathogenic bacteria culture identification and drug sensitivity test. Based on the results, the isolation rate of pathogens strains, the pathogens kind of chronic dacryoeystitis, main pathogens of chronic dacryocystitis, and sensitive drug for pathogens were analyzed.

RESULTS: The isolation rate of pathogens strains was 76.61%(131 cases). The pathogens constituting the chronic dacryocystitis were predominantly gram-positive coccus,the percentage was 72.52%(95 cases), among which staphylococcus hominis occupied 27.48%(36 cases), staphylococcus epidermidis 16.79%(22 cases), streptococcus viridans 12.98%(17 cases). The majority of these bacteria were sensitive to cefoperazone-sulbactam, tobramycin, gentamicin and levofloxacin. For gram-positive coccus, cefoperazone-sulbactam, gentamicin and tobramycin were the most sensitive drug. For gram-negative bacilli, cefoperazone-sulbactam, tobramycin and levofloxacin were most sensitive drug.

CONCLUSION: Staphylococcus hominis is the main pathogen of chronic dacryocystitis, tobramycin can be used as the first choice for local treatment of chronic dacryocystitis.