AIM: To analyze the the ability of optical coherence tomography(OCT)in diagnosis of primary glaucoma through evidence-based medicine,the application of a variety of evaluation and statistical analysis model, provide a reasonable selection of reference to clinicians diagnose glaucoma diagnostic method.

METHODS: The method according to Cochrane systematic reviews, systematic and comprehensive literature was searched PubMed, Web of Science, Medalink, CNKI, CBM, Wanfang Data. Collect all OCT relevant diagnostic test, the quality assessment of diagnostic accuracy studies(QUADAS)items were used to assess the quality of the included studies. The Meta-Disc software was used to analyze the data.

RESULTS: A total of 16 trials were included, The results of Meta-analyses showed that the summary sensitivity, specificity and 95% CI were 0.86(0.84～0.88), 0.90(0.88～0.92). The SROC area under curve(AUC)was for 0.9517.

CONCLUSION: OCT for diagnosis of primary glaucoma has higher sensitivity and specific degree, has great value in clinical application.