角膜缘上皮移植与羊膜移植治疗原发性翼状胬肉的对比观察
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Limbal epithelial autograft transplantation and amniotic membrane transplantation combined with pterygium excision for primary pterygium
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    摘要:

    目的:对比观察翼状胬肉切除联合角膜缘上皮移植术与羊膜移植术对原发性翼状胬肉复发率的影响。

    方法:采用随机对照分组的方法将我院手术治疗的原发性翼状胬肉患者99例103眼随机分为A,B 两组。A组为角膜缘上皮移植术组(n=54眼),采用翼状胬肉切除联合角膜缘上皮移植术; B组为羊膜移植术组(n=49眼),采用翼状胬肉切除联合羊膜移植术。术后随访1a,以泪膜破裂时间(breaking-up time,BUT)、复发率等指标作为分析参考指标。

    结果:术后1a,联合角膜缘上皮移植术组有4眼(7.4%)复发。联合羊膜移植术组有11眼(22. 5%)复发。两组复发率比较,差异有统计学意义(P<0.05)。两组间BUT比较无统计学意义(P>0.05)。

    结论:相比羊膜移植术,翼状胬肉切除联合角膜缘上皮移植术治疗原发性翼状胬肉,能更有效的降低术后复发率。

    Abstract:

    AIM:To compare the recurrence rates between primary pterygium excision with limbal epithelial autograft transplantation and amniotic membrane transplantation.

    METHODS: There were 99 patients(103 eyes)with primary pterygium. These patients were randomly divided into two groups, group A received limbal epithelial autograft transplantation combined with pterygium excision(n=54)and group B received amniotic membrane transplantation(n=49). All patients were followed up with 1a. Breaking-up time(BUT)of tear film and recurrence rates were observed.

    RESULTS: One year after surgery, in the limbal epithelial autograft transplantation group, 4 eyes(7.4%)had recurrence pterygium, in the amniotic membrane transplantation group, 11 eyes(22.5%)had recurrence pterygium, The recurrence rates of the two surgical methods were significantly different(P<0.05). No statistically significant difference was observed between the two groups regarding postoperative tear film BUT(P>0.05).

    CONCLUSION: Limbal epithelial autograft transplantation combined with pterygium excision is superior to amniotic membrane transplantation in terms of recurrence rates.

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许兵,张明昌,高莉.角膜缘上皮移植与羊膜移植治疗原发性翼状胬肉的对比观察.国际眼科杂志, 2014,14(11):2019-2021.

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  • 收稿日期:2014-05-08
  • 最后修改日期:2014-10-21
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  • 在线发布日期: 2014-10-31
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