AIM: To observe the effect of axial length on color Doppler hemodynamic of nonproliferative diabetic retinopathy(NPDR)eye.

METHODS: This is a prospective comparative case series study. The hospitalized patients with diabetic retinopathy from January 2012 to December 2013 in Department of Ophthalmology and Endocrinology of our hospital were included, those with central retinal significant edema, hemorrhage, exudation and significant other fundus lesions were excluded. According to ocular axial length measured by ophthalmologic A/B ultrasound scanner and axial length, the patients were divided into normal axial group(22～<24mm), long axial group(24～<26mm)and super-long axial group(26mm or above). Color Doppler hemodynamic parameters of all patients were measured. Totally, 248 cases(248 eyes)with complete research data were statistically analyzed and were observed the correlation between axial length and eye color Doppler hemodynamics.

RESULTS: Compared with normal axial group, OA PSV(cm/s)of long axial group did not change significantly(t=1.362, P=0.20), CRA PSV(cm/s)was high(t=-2.335, P=0.02), PCA PSV(cm/s)was higher(t=2.756, P=0.01), PI(t=-2.371, -2.585, -2.67; P=0.02, 0.01, 0.01)and RI(t= 2.348, 2.462, 2.293; P=0.02, 0.01, 0.03)is relatively lower, there were statistically significant differences(P<0.05). When compared with super-long axial group, ultra long shaft section OA(t=3.290,P=0.00)low, CRA and PCA PSV of normal axial group was higher(t=3.290, -5.520, -4.900; P=0.00, 0.00, 0.00), PI(t=4.970,6.160,5.990; P=0.00, 0.00, 0.00)and RI(t=-4.310, -5.230, -4.390; P=0.00, 0.00, 0.00)was lower, there was statistically significant differences(P<0.005). When compared with long axial group, OA in PSV(cm/s)of super-long axial group was more slower, but with no statistical significance(t=1.967, P=0.07), CRA PSV(cm/s)was lower(t=-2.543, P=0.01), PCA PSV(cm/s)was higher(t=-2.198, P=0.04), PI(t=-2.331,-2.135, -4.191; P=0.03, 0.03, 0.00)and RI(t=2.570, 2.360, 2.490; P=0.01, 0.02,0.01)was relatively lower, there were significant differences(P<0.05).

CONCLUSION: There is a clear correlation between axial length in diabetic retinopathy and ocular hemodynamics with color Doppler index.