AIM:To explore the clinical outcome of trabeculectomy with mitomycin C(MMC)on glaucoma.

METHODS: A total of 57 patients(95 eyes)of primary glaucoma were randomly divided into two groups, 31 patients(54 eyes)in trabeculectomy with MMC(T+MMC)group, which received trabeculectomy with 0.2mg/mL MMC in surgical sites, and 26 patients(41 eyes)in trabeculectomy(T)group. The anterior chamber, bleb, intraocular pressure(IOP)and complications were observed. The post-operative follow-up periods ranged between 4 and 6mo.

RESULTS: The mean IOP was 11.24±3.73mmHg on 1d in group T+MMC. There was the significant difference compared with preoperative IOP(P<0.01), while no difference with the group T(P>0.05). At final follow-up, the IOP was significantly different between group T+MMC and group T(16.15±3.62mmHg vs 18.79±5.27mmHg, P<0.05). The rate of bleb formation was 94.44% and 80.48% in group T+MMC and T, respectively(P<0.01). The postoperative complications were seldom, hyphema and corneal edema, and were cured finally.

CONCLUSION: Trabeculectomy with MMC for glaucoma can effectively reduce postoperative scar formation of the filtration passage and lower the IOP to a target level with fewer complications.