AIM: To evaluate the clinic efficacy of protein-free calf blood extract ophthalmic gel on healing children dry eye.

METHODS: One hundred patients(50 patients each group)with children dry eye were divided into two groups randomly: control group was dropped 1g/L sodium hyaluronate eye drop four times per day and experimental group was dropped protein-free calf blood extract ophthalmic gel four times per day. Both groups received the depathogeny treatment at the same time. Symptom scores, Schirmer I test values, tear break-up time(BUT), cornea fluorescein staining scores were recorded on the prior treatment and 30d post-treatment, then they were analyzed.

RESULTS: There were statistically significant difference(P<0.05)for the comparison in the symptom scores, Schirmer I test values, BUT, cornea fluorescein staining scores of prior treatment and post-treatment in each groups. And there were statistically significant difference(P<0.05)in the same items of post-treatment between the two groups.

CONCLUSION: There is a clearly beneficial effect of protein-free calf blood extract ophthalmic gel on healing children dry eye.