AIM: To observe the clinical efficacy and safety of glaucoma filtration surgery combined with the application of 5-fluorouracil for clinical treatment to offer the reference.

METHODS:A total of 91 cases of patients with glaucoma treated in our hospital were randomly divided into three groups, 30 cases of group A were given mitomycin in surgery, 31 cases of group B were given 5-fluorouracil, 30 cases of group C were given cyclosporine. They were given 12 -month-follow-up after operation, the operation success rate were recorded, the incidence of 1 -year-adverse reactions, visual acuity, intraocular pressure, low intraocular pressure, shallow anterior chamber, corneal damage index were recorded.

RESULTS: Intraocular pressure ofgroups A, B, C were respectively(20.5±8.6)mmHg,(15.2±5.5)mmHg,(20.0±8.1)mmHg,by the analysis of variance, group B was significantly lower than other two groups,P<0.05; patients of groups A, B, C whose visual acuity increased ratios after 1y were respectively 22.5%, 38.1%,and 23.1%, by the Chi. square test, the increased ratio of group B was higher than other two groups, P<0.05; The operation success rates after 1y of operation of groups A, B, C were respectively 67.5%,88.1%,71.8%,by the Chi square test, the increased ratio of group B was higher than other two groups, P<0.05; The general incidence of adverse reaction were respectively 22.5%,9.5%,20.5%,by the Chi square test, the increased ratio of group B was lower than other two groups, P<0.05.

CONCLUSION:Glaucoma filtration surgery combined with the application of 5-fluorouracil can improve the operation success rate, decrease the occurrence rate of adverse reaction, and safety can be improved.