AIM: To assess the efficacy and safety of trypan blue and indocyanine green(ICG)for continuous curvilineal capsulorrhexis(CCC)in mature or hypermature phacoemulsification.

METHODS:A total of 122 eyes of 122 cases with cataracts in mature and hypermature were randomly divided into three groups, trypan blue staining group was 46 eyes of 46 cases as group A, ICG staining group was 40 eyes of 40 cases as group B, control group was 36 eyes of 36 cases as group C. Staining groups were used to 0.2mL trypan blue or ICG injected into the anterior chamber during operation, respectively. The success rate of CCC, lens posterior capsule rupture and implanted intraocular lens pouch were observed and compared during operation. Anterior chamber inflammation was observed after operation, and compared with the control group to observe and analysis.

RESULTS:The success rate of CCC, implanted intraocular lens pouch were statistically significant difference in trypan blue staining group(group A)than that in control group(group C)(P<0.05). Implanted intraocular lens pouch was statistically significant difference in ICG group(group B)than that in control group(group C)(P<0.05). The rate of lens posterior capsule rupture was no statistically significant difference in all three groups(P>0.05). Anterior chamber inflammation was no significant difference in the postoperative reaction among the three groups.

CONCLUSION:The application of trypan blue or ICG for lens capsule staining before CCC in lack of red reflective mature and hypermature cataracts is safe and effective, both results are comparable. It guarantees a complete CCC and improves the success rate of phacoemulsification.