Research progress of SIRT1 as a target for the treatment of age-related retinal disease
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摘要:
沉默信号调节蛋白1(silent information regulator protein 1，SIRT1)是sirtuins成员之一，属于组蛋白去乙酰化酶，它的活性依赖尼克酰胺腺苷酸二核苷酸(nicotinamide adenine dinucleotide， NAD+)并受其调节。实验及临床研究表明SIRT1在年龄相关性眼病中的神经保护作用。本综述对于SIRT1激动剂-白藜芦醇(RES)与视网膜细胞凋亡之间的关系进行了探讨，并提出SIRT1成为常见年龄相关性视网膜病潜在的治疗靶点。
Abstract:
Silent information regulator protein 1(SIRT1)is one of the sirtuins and belongs to histone deacetyase. Its activity depends on nicotinamide adenine dinucleotide(NAD+)and is regulated by NAD+. Experimental and clinical studies have shown the neuro-protective effect of SIRT1 in the pathogenesis of age-related eye diseases. In this review, the relationship between SIRT1 activator and apoptosis in the retinal cells were discussed. The review also points to SIRT1 as a potential therapeutic target for the clinical management of age-related retinal disease.
