AIM: To compare the clinical efficacy of treatment on recurrent pterygium using different concentration mitomycin C(MMC)in the pterygium excision operation combined with the corneal limbal stem cell autografting(CLSCA).

METHODS: Sixty patients(65 eyes)with recurrent pterygium were randomly divided into three groups. All cases were accepted CLSCA, 21 patients(22 eyes)were given 0.15g/L MMC during operation, 20 patients(22 eyes)were given 0.25g/L MMC during operation, 19 patients(21 eyes)were given 0.4g/L MMC during operation. The patients were followed up for 6mo to 2a.

RESULTS: The recurrent rates of the three groups were 9%, 5%, 5% respectively. There was no statistically significant differences(P>0.05). The complication rates of the three groups were 5%, 36%, 33% respectively. There were statistically significant differences(P<0.05).

CONCLUSION: The treatment to the recurrent pterygium using low concentration MMC has the similar recurrence rates, but the complication rate was lower, it is an ideal operation method, and it is worth popularization and application.