Abstract:AIM:To evaluate the effect and safety of intrachamberal triamcinolone acetonide(TA)injection during cataract surgery on controlling postoperative inflammation and macular edema on diabetic patients.
METHODS: Three hundred patients(300 eyes)with type 2 diabetes who scheduled for cataract surgery were randomly divided into three groups: group A: 0.3% tobramycin/0.1% dexamethasone eye drops and pranoprofen eye drops treatment for 1mo postoperatively; group B: intrachamberal injection of TA 1mg after cataract surgery, and 0.5% levofloxacin eye drops treatment for one month postoperatively; group C: intrachamberal injection of TA 2mg after cataract surgery, and 0.5% levofloxacin eye drops treatment for one month postoperatively. The main measurements included visual acuity, intraocular pressure(IOP), corneal endothelial cell density, anterior chamber inflammation and the thickness of macula of the three groups.
RESULTS: All cataract surgeries were done successfully by a single surgeon. The best corrected vision of group B and C was better than that of group A 1d, 1wk and 1mo postoperatively(P<0.05). The inflammation of anterior chamber of group B and C was milder than that of group A 1d and 1wk postoperatively(P<0.05). The average IOP of group C 1d postoperatively was higher than that of group A(P<0.05). There was no significant difference between group B and group C on the best corrected vision, anterior chamber inflammation and IOP at any time point. No significant change in the macular thickness was found in patients of group B and C before and after cataract surgery, while there was thicker macula in patients of group A 3wk and 1mo postoperatively when comparing with that of the baseline(P<0.05). There was no significant difference among three groups on corneal endothelial cell density at any time point.
CONCLUSION: Intrachamberal TA injection during phacoemulsification can effectively control postoperative inflammation, reduce the macular edema and accelerate the recovery of visual acuity. Intrachamberal TA 1mg has good effect and safety.
