AIM: To investigate the thicknesses change of macula central fovea(MFT)and retinal nerve fiber layer(RNFL)in children with ametropic amblyopia and normal children.

METHODS: The medical records of 56 children with ametropic amblyopia and 56 normal children in our hospital during the same period were retrospectively analyzed. Optical coherence tomography(OCT)was used to measure the MFT and RNFL. The MFT and RNFL change in two groups were statistically evaluated.

RESULTS: The sex, age and axial length were no significant difference between amblyopia group and control group(P>0.05). The MFT in amblyopia group and control group were 135.15±15.15μm, 136.14±14.26μm respectively(P>0.05). The RNFL in amblyopia group and control group were 117.02±8.97μm, 110.43±7.94μm respectively, and there was significant difference(P<0.05). There was negative correlation between RNFL and axial length in control group(r=-0.36, P<0.05), but there was no significant correlation in amblyopiagroup(r=0.11, P>0.05).

CONCLUSION: There are no significant changes in MFT between children with ametropic amblyopia and normal children, but RNFL is thicker in amblyopia group than that in control group, and there is no correlation with axial length.