AIM: To observe the changes of corneal topography and astigmatism et al with various duration of closing eyes and sleep; and study the impact of closing eye and sleep causing physiological hypoxia on corneal topography.

METHODS: Sixteen volunteers were selected(32 eyes), 22-33(26.19 ± 3.95)years old, without refractive errors and other eye diseases, as well as never wearing corneal contact lens, including 10 male eyes and 22 female eyes. The main parameters received corneal simulation K value, corneal astigmatism, corneal irregular measure(CIM)and the shape factor(SF)by Zeiss corneal topographer. They were measured before and after closed eyes 10, 20, 30, 60, 120min; before sleep and after over 6h sleep, they were detected immediately as soon as they opened eyes after 10, 20, 60, 120min.

RESULTS: During closing eyes, there were no statistical significance on the changes of corneal topography, corneal astigmatism, and SF. After opening eyes and over 6h sleep, there were no statistical significance on the changes of corneal topography, corneal astigmatism, CIM, and SF.

CONCLUSION: Closing eyes and sleep don't injure the cornea substantially, so corneal topography and corneal astigmatism don't mainly change.