AIM: To make a analysis of visual quality of iris location guided femtosecond laser assisted in situ keratomi(LASIK)and iris location guided mechanical sub-bowman keratomileusis(SBK)for high myopia treatment.

METHODS:Femtosecond LASIK(study group)was performed in 102 eyes of 51 patients with high myopia and 70 eyes of 35 patients were received mechanical SBK(control group)from January to October 2013. The spherical refraction of all the patients was from -6.00～-9.50D. Best corrected visual acuity(BCVA)of the patients was ≥1.0. Uncorrected visual acuity(UCVA), BCVA, thickness of cornea flap, contrast sensitivity function(CSF)and senior ocular aberration were examined in these patients and follow-up was 1a.

RESULTS: At 1a after surgery 94.1% UCVA in study group reached ≥1.0 and there was 94.3% in control group. There was no significant difference between two groups(P>0.05). Residual refraction of study group was -0.08±0.10 D and control group was -0.10±0.07 D. There was no significant difference of residual refraction between two groups(P>0.05). C12, C8 of senior ocular aberration and RMSH in study group was less than control group, amplification: 0.1642±0.0519 and 0.2229±0.0382(t=8.077, P<0.05), while C7 was equal in two groups: 0.1583±0.1921 and 0.1436±0.1536(t=0.556, P>0.05). C8 was 0.0950±0.069 and 0.1858±0.095(t=7.261, P<0.05). RMSh was 0.3711±0.0847 and 0.5622±0.1033(t=12.801, P<0.05). CSF was no significant difference between study group and control group(P>0.05).

CONCLUSION: Femtosecond LASIK and mechanical SBK is effective for high myopia. Compared to mechanical SBK, femtosecond LASIK shows more advantages in the senior ocular aberration and visual quality. The cornea flap is more regular from central to peripheral area with femtosecond laser.