AIM:To explore the efficacy and safety of mitomycin C used in trabeculectomy by analyzing intraocular pressure and blood flow.

METHODS: A total of 103 patients with glaucoma were divided into 2 groups randomly, and all patients were treated with trabeculectomy, while patients in the observation group were given mitomycin C extra. At 6～12mo follow-up were completed after operation, and the clinical efficacy, complications and hemodynamic characteristics of central retinal artery were compared between groups.

RESULTS: The clinical efficacy of the observation group was higher than that of the controls(P<0.05). There was no significant difference in complication rate between groups(P>0.05), but the complication type was differentiate to some extent. Low intraocular pressure and photophobia symptoms occurred mostly in the observation group, while cicatricial obstruction occurred mostly in the controls. Before treatment, there was no significant difference in hemodynamic characteristics between groups(P>0.05). One month after treatment, the peak systolic velocity(PSV)and end diastolic velocity(EDV)of the observation group were obviously lower, while resistance index(RI)and pulsatility index(PI)were higher than those of the controls, the difference was statistically significant(P<0.05). Six months after treatment, the PSV and EDV of the observation group were obviously higher, while RI and PI were lower than those of the controls, the difference was statistically significant(P<0.05).

CONCLUSION: Mitomycin C has a short-term harmful effect on glaucoma patients after trabeculectomy, but its long-term effect is safe and reliable.