方法：AION患者65例组成AION组，70例非AION患者组成对照组。行颈动脉多普勒超声检查明确AION组及对照组颈动脉粥样硬化发生状况，利用全自动免疫分析仪检测血浆同型半胱氨酸(Hcys)、维生素B12及叶酸水平。对比分析两组颈动脉粥样硬化发生率、血浆Hcys、维生素B12及叶酸水平。

结果：AION组有56例(86%)颈动脉粥样硬化，而对照组为43例(61%)。AION组有59例(91%)血浆Hcys水平升高，对照组为38例(54%)。AION组有37例(57%)血浆维生素B12水平下降，对照组为43例(61%)。AION组有54例(83%)血浆叶酸水平降低，对照组为32例(46%)。AION组及对照组的颈动脉粥样硬化发生率(P=0.001)、血浆Hcys水平(P=0.0005)及叶酸水平(P=0.0006)差异显著，维生素B12水平无差异(P=0.0722)。Logistic回归分析显示颈动脉粥样硬化(OR=1.312，95%CI：0.927～1.772)及血中高Hcys水平(OR=2.378，95%CI：1.479～3.821)是AION的危险因素。

结论：颈动脉粥样硬化、血中高水平的Hcys与AION的发生密切相关，控制这些与血栓有关的危险因素可能有助于AION的防治。

METHODS: Sixty-five AION patients enrolled in AION group and 70 non-AION controls enrolled in control group. All the participants in 2 groups were examined by carotid artery color doppler flow imaging to evaluate the incidence of carotid atherosclerosis. Plasma levels of Hcys, vitamin B12 and folate were measured by automatic biochemical analyzer. The incidence of carotid atherosclerosis, plasma levels of Hcys, vitamin B12 and folate were compared statistically between AION and control group.

RESULTS: Fifty-six AION patients(86%)exhibited carotid atherosclerosis, which was found in 43 control subjects(61%). Fifty-nine AION patients(91%)exhibited increased plasma levels of Hcys compared with that in 38 control subjects(54%). Lowered vitamin B12 was found in 37 patients with AION(57%)and in 43 control subjects(61%). Lowered folate was found in 54 AION patients(83%)and in 32 control subjects(46%). The incidence of atherosclerosis in carotid artery(P=0.001), mean Hcys level(P=0.0005)and lowered folate(P=0.0006)were different statistically between AION group and control group. Mean vitamin B12 level was indifferent between AION group and control group(P=0.0722). Logistic regression analysis showed that carotid atherosclerosis was an a risk factor for AION(OR=1.312, 95%CI: 0.927～1.772), whereas elevated Hcys level(OR=2.378, 95%CI: 1.479～3.821)was also shown to be significant risk factor for AION.

CONCLUSION: Carotid atherosclerosis and elevated Hcys were related with AION. Reducing above-mentioned risk factors related to thrombus may be crucial to the prevention and cure of AION.