AIM:To explore the diagnosis value of retina nerve fiber layer(RNFL)and ganglion cell complex(GCC)in the early stage of chronic primary angle-closure glaucoma(CPACG), and investigate their relationship with mean defect(MD)of visual field.

METHODS: Twenty-one patients with CPACG(38 eyes), 25 patients with suspected glaucoma(SG)(46 eyes)and 25 normal controls(49 eyes)were selected to perform SD-OCT. Statistical difference was analyzed the thickness of RNFL and GCC of average and all quadrants, and correlation between RNFL, GCC and MD of visual field.

RESULTS:There were significant differences in average and all quadrant thickness of RNFL and GCC between CPACG group and control group(P<0.01).The significant differences were found in RNFL thickness(RNFL-Avg, P<0.01; RNFL-Sup, P<0.01; RNFL-Inf, P<0.05)and in GCC thickness(average and all quadrant thickness, P<0.01)between CPACG group and SG group. The positive correlations were showed between MD and RNFL(r=0.65), GCC(r=0.72)in CPACG group.

CONCLUSION:RNFL and GCC are useful to diagnose and monitor the early stage of CPACG, and GCC may be more significant for the disease.