方法：选择我院眼科2012-06/2014-06收治的136例272眼屈光不正性弱视患儿为研究对象，按弱视严重程度(BCVA≥0.5，0.3≤BCVA<0.5，BCVA<0.3)分为轻、中、重度三组，每组又分为<6岁和≥6岁两类。运用PVEP检测各组的LP100及AP100，对比组间差异； 将入选患儿按年龄细分为：4～<6岁、6～<8岁、8～<10岁、≥10岁四个年龄段，以BCVA为因变量，建立包含年龄、等效球镜度、性别、弱视类型的Logistic多因素回归模型，分析年龄与弱视诊断的相关性。

结果：LP100：轻度组<中度组<重度组，三组差异有统计学意义(F=135.22，P<0.01)； AP100：轻度组>中度组>重度组，差异显著(F=16.74，P=0.007)； 轻度、中度、重度弱视组内，<6岁组与≥6岁组比较，LP100显著低(t=8.36、5.37、2.48，P=0.00、0.00、0.02)，AP100显著高(t=6.76、4.88、2.85，P=0.00、0.00、0.01)； 年龄与弱视诊断的独立相关(P<0.01，95% CI： 0.714～0.785)。

结论：年龄是屈光不正性弱视诊断的独立相关因素，同一视力水平在不同年龄段所代表的视功能意义不同，在衡量儿童弱视严重程度时，应对不同年龄段儿童采取不同标准。

METHODS: A total of 136 cases(272 eyes)of children with ametropic amblyopia in our hospital from June 2012 to June 2014 were analyzed. Based on the best corrected visual acuity(BCVA): BCVA ≥0.5, 0.3≤BCVA<0.5, BCVA<0.3, subjects were categorized into three groups: mild group, moderate group and severe group, each group was further divided into two subgroups based on age: <6 years and ≥6 years. The latency(LP100)and amplitude(AP100)of each group were tested by PVEP, an independent samples t test was used to analyze the differences between each age subgroups. Then, age was subdivided into 4 sections(4～<6 years, 6～<8 years, 8～<10 years, ≥10 years), take BCVA as the dependent variable, a Logistic multivariate regression model whose parameters included age, spherical equivalent, gender, type of amblyopia was established to analyze the correlation between age and amblyopia diagnosis.

RESULTS: With an increase in the degree of amblyopia, the LP100 increased and the AP100 decreased. The differences between 3 groups in the LP100 and AP100 were statistically significant(F=135.22, 16.74; P=0.007<0.01); Within the mild, moderate and severe amblyopic groups, the LP100 of the ≥6 years group were longer than those of the <6 years group(t=8.36, 5.37, 2.48; P=0.00, 0.00, 0.02), and the AP100 of the former were less than those of the latter(t=6.76, 4.88, 2.85; P=0.00, 0.00, 0.01). Age was an independent risk factor for amblyopia diagnosis(P <0.01, 95% CI=0.714～0.785).

CONCLUSION: Age is independently associated with the diagnosis of ametropic amblyopia, to different ages of children, the same vision represent different functional significance. In measuring the severity of amblyopia in children, different ages respond to adopt different standards.