Protein unwinding includes advanced structure changes, the formation and fracture of disulfide bond and so on. Protein unwinding is widely involved in the physiological and pathological processes in vivo, of which advanced structure changes have important influences on the occurrence and development of conformational diseases. In order to seek for the common pathological mechanism and corresponding intervention approach, this review summarizes the current information about conformational diseases, especially about cataract and Alzheimer's disease.