Collagen protein has special biological characteristics and physical properties, including quaternary structure, low immunogenicity, biocompatibility, biodegradability and hemostatic properties and so on, which are the foundation of collagen protein being widely used and it has important relationship with the occurrence and development of some eye diseases, such as keratoconus, conjunctivochalasis, high myopia, etc. This paper reviews the recent progress of collagen protein in eye diseases.