Retinal neovascularization diseases are the major causes of blindness. C-C chemokine receptor type 7(CCR7)can promote the expression of vascular endothelial growth factor(VEGF)through the extracellular signal regulated kinase(ERK)pathway, leading to vascular leakage, proliferation of vascular endothelial cell, neovascularization and etc. The detection of CCR7 can guide the diagnosis and treatments of retinal neovascularization diseases.