AIM:To investigate the clinical effect of Conbercept intravitreal injection combined with 577nm micro-pulse laser on the treatment of diabetic macular edema(DME).

METHODS:From June to December in 2014, after the diagnosis was confirmed by fundus examination, fundus fluorescein angiography(FFA)and optical coherence tomography(OCT), 64 patients(64 eyes)from department of ophthalmology in Baoji People's Hospital with DME were randomly divided into experiment group(32 cases)and control group(32 cases). The experiment group received 577nm micro-pulse laser combined with intravitreal injection of Conbercept. The control group was treated with 577nm micro-pulse laser. The best corrected visual acuity(BCVA)and central macular thickness(CMT)of two groups before and after treatments were compared.

RESULTS:The ANOVA for two-way repeated measures was used to analyze the data of BCVA and CMT between two groups. The results showed that the interaction between treatment effects and time effects in BCVA and CMT was significant(F=46.92,P<0.01; F=60.231,P<0.01), the main effect of the treatment were significant(F=12.16,P<0.01; F=8.983,P<0.01). There was significant difference on the effect between the two treatments, BCVA and CMT of experiment group were better than those of control group. The main time effect was statistically significant(F=116.14,P<0.01; F=397.376,P<0.01). The BCVA means increased with the treatment time, but the CMT means decreased.

CONCLUSION: Intravitreal injection of Conbercept combined with 577nm micropulse laser on the treatment of DME was much better on reducing macular edema and improving visual acuity than the micro-pulse treatment.