AIM: To periodically evaluate the anisometropia amblyopic children's activation of the visual cortex function after training normatively by blood oxygen level dependent-functional magnetic resonance imaging(BOLD-fMRI).

METHODS:Thirteen children with anisometropia amblyopic from advanced research and subsequent research were collected. Self-controlled study before and after treatment and blocks-designed fMRI was performed. fMRI data were processed by using SPM8 which based on the Matlab 7.12.0.635. T test was used to compare and analyze the difference of the brain activation data before and 18, 24mo after amblyopia treatment and 6mo after stopped treatment.

RESULTS: The activation ranges in all these periods are Brodmann 7, 17, 18, and 19; After normalized treatment 24mo(mean T=1.014; P>0.01). and after stopped treatment 6mo(mean T=0.9793, P>0.01). The increasing of the activation ranges in visual cortex was unconspicuous.

CONCLUSION: Visual cortex is basically stable after 2a of anisometropic amblyopia treatment, and continuous treatment for amblyopia has no significant effect on visual cortex function reconstruction.