AIM:To study the effect of multilayer amniotic membrane covering therapy for the treatment of traumatic corneal injury or perforation in children.

METHODS:Sixty cases(72 eyes)were randomly selected from the children with traumatic corneal injury or perforation from May 2012 to May 2015 in our hospital. They were divided into two groups according to the different treatments, the study group(30 patients with 36 eyes)and the control group(30 patients with 36 eyes). The patients in control group were given single layer amniotic membrane covering treatment, while those in study group were given multilayer amniotic membrane covering treatment.

RESULTS:The duration of the amniotic membrane of the study group was significantly longer than that of the control group(P<0.05). The corneal edema time was significantly shorter(P<0.05). The rate of patients who had angiogenesis <3 quadrants was 28%(10/36), which was significantly higher than that of the control group 17%(6/36)(P<0.05). The rate of patients without angiogenesis was 11%(4/36), which was significantly lower than that of the control group 28%(10/36)(P<0.05). The rate of patients with the visual acuity 0.3 ～1.0 in observation group was 11%(4/36), which was significantly higher than that of the control group 3%(1/36)(P<0.05). The rate of patients with visual acuity hand motion/before eyes～0.1 was 56%(20/36), which was significantly lower than that of the control group 72%(26/36)(P<0.05).

CONCLUSION:The multilayer amniotic membrane covering therapy was effective on the treatment of traumatic corneal injury or perforation in children.