AIM:To investigate the effects of combined with bromfena sodium 0.1% eye drops and steroids eye drops on cataract surgery, then further study its safety and effectiveness on phaeoemulsfieation.

METHODS:A prospective, randomized, controlled study including 100 patients(120 eyes), enrolled for cataract surgery. The patients were randomized to topical treatment with Tobramycin and Dexamethasone combined with bromfenac sodium 0.1%(trial group, 60 eyes)or Tobramycin and Dexamethasone(control group, 60 eyes). Scleral tunnel incision phacoemulsification cataract extraction and intraocular lens implantation was used. The sign, symptom, intraocular pressure(IOP)and optical coherence tomography(OCT)were determined postoperative 1, 7, 14d.

RESULTS:There were significant differences in symptoms and signs between two groups at postoperative 7 and 14d(P<0.05)and no difference at postoperative 1d(P>0.05). The value of the trial group was lower than that of the control group. Preoperative IOP was 14.657±2.605mmHg in trial group and 14.415±2.761mmHg in control group, the difference was not statistically significant(P>0.05). IOP in trial group were lower than that of control group at postoperative 1, 7, 14d, the difference was statistically significant(P<0.05). In the control group, the incidence of macular edema at postoperative 1, 7, 14d were 1.7%, 1.7% and 3.3%, respectively, which was significantly higher than those of trial group(0, 0, 1.7%). The difference was statistically significant(P<0.05).

CONCLUSION:Application of 0.1% bromfenac sodium eye drop and Tobramycin and Dexamethasone eye drops for cataract extraction and intraocular lens implantation in the treatment of postoperative inflammation has better treatment effect. It is safe and effective, and less prone to ocular hypertension and other serious complications; At the same time it can significantly reduce the incidence of postoperative macular edema, prevention of macular edema after cataract surgery, with security and reliability, worthy of clinical application.