AIM:To investigate the influence of ocular perfusion pressure fluctuation on glaucoma.

METHODS:Forty patients with primary open angle glaucoma from January 2013 to June 2015 in our hospital were used as observation group and 40 families were used as control group. Circadian fluctuation of intraocular pressure, blood pressure and ocular perfusion pressure in 24h were determined to obtain systolic ocular perfusion pressure(SOPP), diastolic ocular perfusion pressure(DOPP)and mean ocular perfusion pressure(MOPP). Pearson linear correlation was used to analyze the correlation of circadian MOPP fluctuation with cup-disc ratio, mean defect(MD)and the picture standard deviation(PSD).

RESULTS:The fluctuation of MOPP, SOPP and DOPP of observation group were significantly higher than those of control group(P<0.05). MOPP fluctuation was negatively correlated with MD(r=-0.389, 95%CI:-0.612～-0.082; P=0.011), was positively correlated with PSD(r=0.512, 95%CI:0.139 ～0.782; P=0.008); no correlation was found between it and the vertical cup-disc ratio(r=0.115, 95%CI:0.056～0.369; P=0.355).

CONCLUSION:Ocular perfusion pressure fluctuations in patients with primary open angle glaucoma may reflect the severity of the disease and may make the situation aggravating. Therefore through perfusion pressure monitor in 24h may help us understand the ocular blood flow and the development of primary open-angle glaucoma.