AIM:To study the relationship between inducible nitric oxide synthase(iNOS)and vascular endothelial factor CD34 with the incidence of recurrent pterygium.

METHODS:From March 2012 to October 2014, 15 patients with recurrent pterygium were treated as the experimental group of this study and 15 cases with simple pterygium were selected as the control group. iNOS and CD34 in two groups of patients were detected by immunohistochemical Envision method. Microvessel density(MVD)was calculated. The positive expression rates of iNOS and CD34 and MVD in the two groups were compared, and the effect of iNOS and CD34 on recurrent pterygium was analyzed.

RESULTS:The positive expression rate of iNOS was 7%(1 case)in the control group and 87%(13 cases)in the experimental group. The positive expression rate of CD34 in control group was 13%(2 cases)and was 80%(12 cases)in the experimental group. The positive expression rate of iNOS and CD34 in the patients with recurrent pterygium were significantly higher than those in the normal group(P<0.01). The MVD value of the experimental group was 46.02±10.88, and the control group MVD was 23.48±5.68. The MVD of the experimental group was significantly higher than that of the control group and the difference between the two groups was statistically significant(P<0.01).

CONCLUSION:iNOS and CD34 were significantly higher in the patients with recurrent pterygium. The relationship between iNOS and CD34 was related to the occurrence and development of recurrent pterygium.